| 產(chǎn)品編號(hào) | bsm-61101R |
| 英文名稱 | Caveolin-2 Recombinant Rabbit mAb |
| 中文名稱 | 細(xì)胞質(zhì)膜微囊蛋白-2重組兔單抗 |
| 別 名 | CAV2; Caveolae protein 20 Kd; Caveolin 2; Caveolin 2 isoform a and b; Caveolin-2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 18 kDa |
| 檢測(cè)分子量 | 18 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Caveolin 2: 1-50 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. SWISS: P51636 Gene ID: 858 Caveolin是細(xì)胞生長(zhǎng)相關(guān)信號(hào)途徑及腫瘤發(fā)生發(fā)展過程中重要的抑制因子，Caveolae是細(xì)胞膜內(nèi)的特殊膜結(jié)構(gòu)，參與包括細(xì)胞的分子運(yùn)輸、細(xì)胞粘附和信號(hào)轉(zhuǎn)導(dǎo)在內(nèi)的多種細(xì)胞活動(dòng)。Caveolin-1是Caveolae中重要的結(jié)構(gòu)蛋白，抑制細(xì)胞生長(zhǎng)，與多種人類腫瘤發(fā)生發(fā)展相關(guān)的信號(hào)分子相互作用。Caveolin在信號(hào)轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。Caveolin構(gòu)成了一個(gè)蛋白家族，他們是細(xì)胞質(zhì)膜中發(fā)夾樣結(jié)構(gòu)域的主要結(jié)構(gòu)成分。Caveolin在信號(hào)轉(zhuǎn)導(dǎo)的整合中起支架蛋白的作用。至今已經(jīng)鑒定了3種Caveolin |
| 產(chǎn)品圖片 |
Western blot analysis of in HeLa cell lysate. Using Caveolin-2 (bsm-61101R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
4% Paraformaldehyde-fixed Hela (H) cell; Triton X-100 at r.t. for 20 min; Antibody incubation with (Caveolin-) monoclonal Antibody, unconjugated (bsm-61101R) 1:100, 90 min at 37°C; followed by conjugated Goat Anti-Rabbit IgG antibody (green, bs-60295G-BF488) at 37°C for 90 min, DAPI (blue, C02-04002) was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
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