| 產(chǎn)品編號 | bsm-0940M |
| 英文名稱 | LAMR1(5D4) Mouse mAb |
| 中文名稱 | 層粘連蛋白受體1單克隆抗體 |
| 別 名 | 37LRP; P37-kDa laminin receptor precursor; MGr1-Ag; laminin receptor 1; 67kD, ribosomal protein SA; 34/67 kDa laminin receptor; 40S ribosomal protein SA; 67LR; Colon carcinoma laminin-binding protein; LAMBR; Laminin Receptor 1; LAMR 1; LAMR1; LRP; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; p40; Ribosomal Protein SA; RPSA; 67kD laminin receptor. |
 |
Specific References (1) | bsm-0940M has been referenced in 1 publications.
[IF=2.4] Wang, Leilei, et al. "67‐kDa Laminin Receptor (LR1) Contributes to Hypoxia‐induced Migration and Invasion of Trophoblast‐like Cells by Mediating Matrix Metalloproteinase (MMP)‐9." Clinical and Experimental Pharmacology and Physiology (2015). WB ; Human.
|
| 研究領(lǐng)域 | 腫瘤 細(xì)胞凋亡 細(xì)胞膜受體 |
| 抗體來源 | Mouse |
| 克隆類型 | Monoclonal |
| 克 隆 號 | 5D4 |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32.7 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì) |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LAMR1: 2-100/295 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein G |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Subunit: Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. Interacts with PRNP. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B. Subcellular Location: Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane. Post-translational modifications: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. Similarity: Belongs to the ribosomal protein S2P family. SWISS: P08865 Gene ID: 3921 Database links: Entrez Gene: 3921 Human Entrez Gene: 100505031 Mouse Entrez Gene: 16785 Mouse Omim: 150370 Human SwissProt: P08865 Human SwissProt: P14206 Mouse Unigene: 449909 Human Unigene: 311972 Mouse Unigene: 391708 Mouse Unigene: 4071 Mouse Unigene: 121972 Rat Unigene: 161973 Rat Unigene: 999 Rat 層粘連蛋白受體1（37LRP）是層粘連蛋白受體重要的前體，是近期發(fā)現(xiàn)的-胃癌耐藥相關(guān)蛋白。 |
