| 產(chǎn)品編號(hào) | bs-1636R |
| 英文名稱 | SERPINC1 Rabbit pAb |
| 中文名稱 | 抗凝血酶3抗體 |
| 別 名 | AntithrombinIII; Antithrombin III; Antithrombin-III; AT 3; AT III; AT3; ATIII; MGC22579; Serine(or cysteine) proteinase inhibitor clade C(antithrombin) member 1; Serine Proteinase Inhibitor Clade C Member 1; SERPIN C1; Serpin peptidase inhibitor clade C(antithrombin) member 1; ATH III; Antithrombin 3; ANT3_HUMAN. |
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Specific References (1) | bs-1636R has been referenced in 1 publications.
[IF=1.747] Zhang X et al. Extraction, purification, characterization, anticoagulant activity, and anticoagulant mechanism of polysaccharides from the heads of Hypomesus olidus. Food Science & Nutrition. 2019. Other ; Human.
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| 研究領(lǐng)域 | 心血管 細(xì)胞生物 合成與降解 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Pig,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 51 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Antithrombin III: 141-211/464 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Phosphorylation sites are present in the extracellular medium. Similarity: Belongs to the serpin family. SWISS: P01008 Gene ID: 462 Database links: Entrez Gene: 462 Human Entrez Gene: 11905 Mouse Omim: 107300 Human SwissProt: P01008 Human SwissProt: P32261 Mouse Unigene: 75599 Human Unigene: 260770 Mouse Unigene: 204806 Rat |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Antithrombin III /SERPINC1) Polyclonal Antibody, Unconjugated (bs-1636R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Antithrombin III /SERPINC1) Polyclonal Antibody, Unconjugated (bs-1636R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Tissue/cell: mouse spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Antithrombin III Polyclonal Antibody, Unconjugated(bs-1636R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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