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MEPE Rabbit pAb (bs-8689R)  
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產(chǎn)品編號 bs-8689R
英文名稱 MEPE Rabbit pAb
中文名稱 細胞外基質磷酸化抗體
別    名 Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45.  
Specific References  (1)     |     bs-8689R has been referenced in 1 publications.
[IF=3.423] Baris Ozgur Donmez. et al. Calcium?dependent activation of PHEX, MEPE and DMP1 in osteocytes. MOL MED REP. 2022 Dec;26(6):1-11  WB ;  Mouse.  
研究領域 免疫學  發(fā)育生物學  信號轉導  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse
產(chǎn)品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 56 kDa
檢測分子量
細胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MEPE: 201-300/525 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 MEPE is a 525 amino acid extracellular matrix protein. Expressed in osteocytes and brain, MEPE is a regulator of bone metabolism that is thought to mediate mineralization and demineralization within the osteocyte microenvironment. MEPE contains an RGD cell-attachment motif and shares molecular similarities with several dentin-bone extracellular matrix RGD-containing phosphoglycoproteins, including OPN (osteopontin) and DSP (dentin sialophosphoprotein). Via its ability to control bone mineralization, MEPE is associated with various developmental events such as skeletogenesis, bone regeneration and odontogenesis. MEPE is secreted in hypophosphatemic osteomalacia tumors, suggesting a possible role in the pathophysiology of bone-related cancers.

Function:
Seems to play a role in mineralization.

Subcellular Location:
Secreted

Tissue Specificity:
Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors.

Post-translational modifications:
Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif.

SWISS:
Q9NQ76

Gene ID:
56955

Database links:

Entrez Gene: 56955 Human

Entrez Gene: 94111 Mouse

Entrez Gene: 79110 Rat

Omim: 605912 Human

SwissProt: Q9NQ76 Human

Unigene: 676357 Human

Unigene: 196672 Mouse

Unigene: 160717 Rat



產(chǎn)品圖片
Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Spleen tissue lysates Lane 4: Mouse Cerebellum tissue lysates Lane 5: Human HepG2 cell lysates Lane 6: Human MCF-7 cell lysates Primary: Anti-MEPE (bs-8689R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 47,62 kDa
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