| 產(chǎn)品編號(hào) | bs-4957R |
| 英文名稱 | CRTAM Rabbit pAb |
| 中文名稱 | T細(xì)胞調(diào)控相關(guān)蛋白抗體 |
| 別 名 | CD355; Class I MHC restricted T cell associated molecule; Class-I MHC-restricted T-cell-associated molecule; CRTAM; CRTAM_HUMAN; Cytotoxic and regulatory T cell molecule; Cytotoxic and regulatory T-cell molecule. |
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Specific References (1) | bs-4957R has been referenced in 1 publications.
[IF=5.1] Hinman Jason D. et al. miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy. Hum Mol Genet. 2021 Feb;: IF ; Mouse.
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| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞類型標(biāo)志物 自然殺傷細(xì)胞 淋巴細(xì)胞 t-淋巴細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig) |
| 產(chǎn)品應(yīng)用 | ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 42 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRTAM: 31-130/393 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
CRTAM, (class-I MHC-restricted T-cell associated molecule), is an immunoglobulin-superfamily transmembrane protein and a new member of the nectin-like (Necls) family. In the immune system, CRTAM expression has been shown to be restricted to activated class-I MHC-restricted T cells, including NKT and CD8 T cells. CRTAM interacts with CADM1 and promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Nectin-like (Necl) molecule 2, has been identified as a ligand of CRTAM. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system. Function: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Subunit: Interacts with CADM1. Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. Similarity: Belongs to the nectin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: O95727 Gene ID: 56253 Database links: Entrez Gene: 56253 Human GenBank: BC070266.1 Human Omim: 612597 Human SwissProt: O95727 Human Unigene: 159523 Human CRTAM蛋白與調(diào)節(jié)細(xì)胞極性有關(guān)。細(xì)胞極性（cell polarity）的調(diào)控對(duì)于控制細(xì)胞的形態(tài)發(fā)生非常關(guān)鍵，并且這一過(guò)程在很多生物學(xué)功能中發(fā)揮著重要的作用，包括細(xì)胞分裂、分化、遷移等基礎(chǔ)過(guò)程以及器官發(fā)生中的復(fù)雜行為等。細(xì)胞蛋白的空間結(jié)構(gòu)排列是細(xì)胞極性形成的基礎(chǔ)。抗原呈遞細(xì)胞（antigen-presenting cell，APC）誘導(dǎo)T細(xì)胞的激活，而這會(huì)導(dǎo)致免疫突觸（immunological synapse，IS）的形成、T細(xì)胞受體（TCR）接觸信號(hào)銜接平臺(tái)的組裝、細(xì)胞支架的重組以及第二信使的產(chǎn)生等。 |
