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Destrin Rabbit pAb (bs-12997R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-12997R
英文名稱(chēng) Destrin Rabbit pAb
中文名稱(chēng) 肌動(dòng)蛋白解聚因子抗體
別    名 2610043P17Rik; ACTDP; Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AU042046; bA462D18.2; corn1; DEST_HUMAN; Destrin(actin depolymerizing factor); Destrin; DSN; Dstn; Sid 23; sid23p.  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  結(jié)合蛋白  細(xì)胞骨架  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) (predicted: Human,Mouse,Rat,Rabbit,Cow,Dog,Horse,Monkey)
產(chǎn)品應(yīng)用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 19 kDa
檢測(cè)分子量
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Destrin: 75-165/165 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

Function:
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.

Tissue Specificity:
Widely distributed in various tissues.

Post-translational modifications:
ISGylated.

Similarity:
Belongs to the actin-binding proteins ADF family.
Contains 1 ADF-H domain.

SWISS:
P60981

Gene ID:
11034

Database links:

Entrez Gene: 11034 Human

Entrez Gene: 56431 Mouse

Entrez Gene: 502674 Rat

Omim: 609114 Human

SwissProt: P60981 Human

SwissProt: Q9R0P5 Mouse

SwissProt: Q7M0E3 Rat



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