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AMCase Rabbit pAb (bs-21956R)  
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產品編號 bs-21956R
英文名稱 AMCase Rabbit pAb
中文名稱 哺乳動物酸性幾丁質酶抗體
別    名 CHIA; Acidic mammalian chitinase [Precursor]; CHIT2; chitinase, acidic; DKFZp313J1722; ECF L; RP5 1125M8.1; TSA1902.  
研究領域 細胞生物  免疫學  信號轉導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Human,Rat,Pig,Horse)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 50 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AMCase : 201-300/476 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Function:
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.

Subcellular Location:
Isoform 1: Secreted Isoforms 2 and 3: Cytoplasmic

SWISS:
Q9BZP6

Gene ID:
27159

Database links:
Entrez Gene: 27159 Human

Entrez Gene: 81600 Mouse

Entrez Gene: 113901 Rat

GenBank: NM_021797.2 Human

Omim: 606080 Human

SwissProt: Q9BZP6 Human

SwissProt: Q91XA9 Mouse

SwissProt: Q6RY07 Rat

Unigene: 46418 Mouse



產品圖片
Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti- AMCase (bs-21956R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kD Observed band size: 50 kD
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