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Mouse Thrombomodulin/BDCA-3 ELISA Kit (bsk12033)  
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96T/2900.00元
大包裝/詢價
產品編號 bsk12033
英文名稱 Mouse Thrombomodulin/BDCA-3 ELISA Kit
中文名稱 小鼠凝血酶調節(jié)蛋白酶聯免疫試劑盒
別    名 Thrombomodulin; CD 141; CD141; CD141 antigen; Fetomodulin; THBD; THRM; TM; AHUS 6; AHUS6; BDCA 3; BDCA3; THPH12  
克 隆 號
種    屬 Mouse
線性范圍 93.80 - 6,000 pg/mL
應用范圍 S/P/CC
檢測限 50 pg/mL
適用樣品基質 cell culture supernates, serum, and plasma.
保存條件 Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.).
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 Thrombomodulin, TM is cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway. It located in a vein, artery and capillary endothelial cells on the surface of plasma membrane protein. It is generally believed: TM vascular endothelial injury is an important parameter is the thrombin receptor, known in a variety of normal human tissues, can also be expressed in many tumors, TM may be similar to the E-cadherin,and is a lectin Like activity of a new class of members of the cell adhesion molecules. CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

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