| 產(chǎn)品編號 | bsm-60774R |
| 英文名稱 | Mannan Binding Lectin Recombinant Rabbit mAb |
| 中文名稱 | 甘露聚糖結(jié)合凝集素重組兔單克隆抗體 |
| 別 名 | Mbl2; L-MBP; MBL; MBL-C; MBP-C; COLEC 1; COLEC1; HSMBPC; Mannan binding protein; Mannose binding lectin(protein C) 2 soluble; Mannose binding lectin 2 soluble; Mannose binding lectin; Mannose binding lectin protein C2 soluble opsonic defect; Mannose binding protein; Mannose binding protein C; Mannose binding protein C precursor; MBL 2; MBP 1; MBP; MBP C; MBP1; MBPC; MGC116832; MGC116833; Opsonic defect; protein C; Soluble mannose binding lectin; MBL2_HUMAN. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 18B9 |
| 交叉反應(yīng) | Mouse (predicted: Human) |
| 產(chǎn)品應(yīng)用 | WB=1:500-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Mannan Binding Lectin |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | PBS, Glycerol, BSA. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]. Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Subunit: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity. Subcellular Location: Secreted. Tissue Specificity: Plasma protein produced mainly in the liver. Similarity: Contains 1 C-type lectin domain. Contains 1 collagen-like domain. SWISS: P11226 Gene ID: 4153 Database links: Entrez Gene: 4153 Human Entrez Gene: 17195 Mouse Omim: 154545 Human SwissProt: P11226 Human SwissProt: P41317 Mouse Unigene: 499674 Human Unigene: 30045 Mouse MBL （mannan binding lectin）甘露聚糖結(jié)合凝集素，MBL是一種兼有調(diào)理素和直接激活補(bǔ)體功能的免疫分子，參與構(gòu)成抗感染的第一道防線。MBL2在發(fā)生急性期反應(yīng)時由肝臟分泌，并參與天然免疫防御。凝集素配體可以存在于各種各樣的微生物中，兩者結(jié)合后可以導(dǎo)致調(diào)理作用并激活補(bǔ)體系統(tǒng)。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Liver tissue lysates
Lane 2: Mouse Plasma tissue lysates
Primary: Anti-Mannan Binding Lectin (bsm-60774R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 26 kDa
Observed band size: 26 kDa
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