| 產(chǎn)品編號 | bs-1611R-AP |
| 英文名稱 | Rabbit Anti-Cathepsin K/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的組織蛋白酶K抗體 |
| 別 名 | Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostosis; cath-K; CK. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 合成與降解 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Guinea Pig, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cathepsin K |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]. Function: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Subunit: Belongs to the peptidase C1 family. Subcellular Location: Lysosome. Tissue Specificity: Tissue specificityPredominantly expressed in osteclasts (bones). DISEASE: Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Similarity: Belongs to the peptidase C1 family. Database links: Entrez Gene: 1513 Human Entrez Gene: 13038 Mouse Omim: 601105 Human SwissProt: P43235 Human SwissProt: P55097 Mouse Unigene: 632466 Human Unigene: 272085 Mouse Unigene: 5598 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） 組織蛋白酶K(cathepsinK)是半胱氨酸蛋白酶家族的成員,它和組織蛋白酶S、L和B有很高的同源性。 在心血管方面：組織蛋白酶K參與心血管的很多病理生理過程，在動脈硬化、血管重塑與再生。也是動脈瘤生長、破裂、主動脈辯狹窄進(jìn)程中主要的膠原酶之一。 在骨與關(guān)節(jié)方面：組織蛋白酶K主要位于破骨細(xì)胞，是涉及骨質(zhì)再吸收的主要酶，與骨質(zhì)疏松與脫鈣密切相關(guān)。 |
