| 產(chǎn)品編號(hào) | bs-0257R-BF488 |
| 英文名稱 | Rabbit Anti-MAG/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的髓鞘相關(guān)糖蛋白a/b抗體 |
| 別 名 | GMA; MAG; MAG_HUMAN; Myelin associated glycoprotein; Myelin-associated glycoprotein; S MAG; Siglec 4a; Siglec-4a; SIGLEC4A. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAG-a/b |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MAG (myelin associated glycoprotein) is a Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3-linked sialic acid. Isoform L-MAG is critical for the formation of myelin in the CNS, whereas isoform S-MAG is sufficient to maintain the integrity of myelin in PNS. Binds to RTN4R. single-pass type I membrane protein. Expressed by myelinating glial cells in the central and peripheral nervous system. Detected in oligodendrocyte processes before formation of compact myelin. Restricted to the periaxonal space after myelination. Isoform S-MAG is the predominant isoform in CNS and PNS of the adult. In CNS isoform L-MAG is the major form synthesized early in development, and it persists as a significant proportion of the MAG present in the adult. In the PNS isoform L-MAG is expressed at modest levels during development; it is absent in the adult. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Function: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid. Subunit: Binds to RTN4R. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Entrez Gene: 4099 Human Entrez Gene: 17136 Mouse Omim: 159460 Human SwissProt: P20916 Human SwissProt: P20917 Mouse Unigene: 643440 Human Unigene: 241355 Mouse Unigene: 87331 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 髓鞘相關(guān)糖蛋白a/b（MAG-a/b）又稱：髓磷脂相關(guān)的球蛋白 髓鞘相關(guān)糖蛋白(myelin-associated glycoprotein, MAG)是免疫球蛋白超家族成員，它由中樞神經(jīng)系統(tǒng)的少突膠質(zhì)細(xì)胞和外周神經(jīng)系統(tǒng)的施萬細(xì)胞表達(dá)。 MAG定位于直接和軸突相接觸的髓鞘膜的最里層，它通過介導(dǎo)膠質(zhì)細(xì)胞與軸突的相互作用參與髓鞘的形成及其完整性的維持。同時(shí)MAG也是髓鞘來源的神經(jīng)生長(zhǎng)抑制因子的主要成分。在神經(jīng)系統(tǒng)發(fā)育的不同階段，MAG顯示不同的功能:即發(fā)育期促進(jìn)軸突生長(zhǎng)，成熟期抑制軸突生長(zhǎng)。其抑制作用主要由髓鞘來源的抑制分子的共同受體NgR介導(dǎo)，在神經(jīng)營(yíng)養(yǎng)因子受體p75NTR以及小GTP酶Rho等信號(hào)分子的共同參與下完成。 |
