| 產(chǎn)品編號 | bs-16955R-Gold |
| 英文名稱 | Rabbit Anti-KHDRBS2/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的KHDRBS2蛋白抗體 |
| 別 名 | 6330586C16Rik; bA535F17.1; FLJ38664; hSLM 1; KH domain containing, RNA binding, signal transduction associated 2; KHDRBS2; MGC26664; Sam68 like mammalian protein 1; SLM 1; SLM1. |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細胞生物 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KHDRBS2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: KHDRBS2 (KH domain containing, RNA binding, signal transduction associated 2), is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. It induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer and may function as an adapter protein for Src kinases during mitosis. KHDRBS2 binds both poly(A) and poly(U) homopolymers. Function: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Subunit: Self-associates to form homooligomers. Subcellular Location: Nuclear Tissue Specificity: Highly expressed in brain, lung, kidney and small intestine. Weakly expressed in placenta, liver, spleen,thymus, ovary and colon. Similarity: Belongs to the KHDRBS family. Contains 1 KH domain. Database links: Entrez Gene: 202559 Human Entrez Gene: 170771 Mouse GenBank: NM_152688 Human Omim: 610487 Human SwissProt: Q5VWX1 Human SwissProt: Q9WU01 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
