| 產(chǎn)品編號 | bs-18947R-BF488 |
| 英文名稱 | Rabbit Anti-MITD1/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的MITD1蛋白抗體 |
| 別 名 | Microtubule interacting and transport domain containing 1; MIT; MIT domain containing protein 1; MIT microtubule interacting and transport domain containing 1; MITD 1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MITD1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 產(chǎn)品介紹 |
background: MITD1 is a 249 amino acid peripheral membrane protein that localizes to the cytoplasmic side of late endosomes, where it is Implicated in endosomal protein transport. MITD1 interacts with CHMP2 and CHMP1B, and is encoded by a gene that maps to human chromosome 2q11.2. As the second largest human chromosome, chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene. Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. Subunit: Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1. Subcellular Location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Similarity: Contains 1 MIT domain. Database links: Entrez Gene: 129531 Human Entrez Gene: 69028 Mouse SwissProt: Q8WV92 Human SwissProt: Q8VDV8 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
