| 產(chǎn)品編號(hào) | bs-10058R-Gold |
| 英文名稱 | Rabbit Anti-MMP19/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的基質(zhì)金屬蛋白酶18/19抗體 |
| 別 名 | Matrix metalloproteinase 18; Matrix metalloproteinase 19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; MMP 18; MMP 19; MMP-18; MMP-19; MMP18; MMP19; MMP19_HUMAN; RASI 1; RASI; RASI1. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 免疫學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MMP19 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. Post-translational modifications: Activated by autolytic cleavage after Lys-97. DISEASE: Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Database links: Entrez Gene: 4327 Human Omim: 601807 Human SwissProt: C0M4B0 Human SwissProt: Q99542 Human Unigene: 154057 Human Unigene: 591033 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
