| 產(chǎn)品編號 | bs-2299R-BF488 |
| 英文名稱 | Rabbit Anti-phospho-STMN2 (Ser50)/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的磷酸化神經(jīng)生長相關(guān)蛋白SCG10抗體 |
| 別 名 | Neuronal growth associated protein; SCG 10; SCG10; SCG10 protein; SCGN 10; SCGN10; SGC 10; SGC10; Stathmin 2; Stathmin like 2; STMN 2; STMN-2; Superior cervical ganglia neural specific 10; Superior cervical ganglion 10 protein; Superiorcervical ganglia neural specific 10. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 產(chǎn)品類型 | 磷酸化抗體 |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat, (predicted: Human, Mouse, Chicken, Dog, Horse, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human STMN2 around the phosphorylation site of Ser50 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]. Function: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Subunit: Interacts with MAPK8. Interacts with ITM2C. Subcellular Location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cell projection, axon. Golgi apparatus. Endosome. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Tissue Specificity: Neuron specific. Post-translational modifications: Sumoylated. Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15. Similarity: Belongs to the stathmin family. Database links: Entrez Gene: 11075 Human Entrez Gene: 20257 Mouse Omim: 600621 Human SwissProt: Q93045 Human SwissProt: P55821 Mouse Unigene: 521651 Human Unigene: 29580 Mouse Unigene: 34335 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. STMN2神經(jīng)生長相關(guān)蛋白又稱：頸上神經(jīng)節(jié)神經(jīng)特異性因子10，該蛋白可調(diào)節(jié)神經(jīng)細(xì)胞的分化、神經(jīng)細(xì)胞軸突的增殖及細(xì)胞骨架的構(gòu)成。 |
